Receiving the Indian Council of Medical Research (ICMR) Dr. Dharamvir Datta Memorial Oration Award for research work in Liver Diseases in India for the year 2018 from Honorable Minister of Health and Family Welfare Dr.  Harsh Vardhan.

I am a member of the faculty (Associate Professor)  in the Department of Bioengineering and Technology, Gauhati University since February 2010. Has completed  B.Sc- Biotechnology from St. Anthony’s College Shillong (1999) , M.Sc -Biotechnology from Gauhati University (2002) after which has joined ICAR research Complex-NEH region barapani in the division of Animal Health (2002-03)  as a Research Fellow and learned some of the basic techniques in Molecular Biology. Then  has served as a faculty members in the Department of Biotechnology at Cyber Research Training Institute, Burdwan (University of Burdwan ) from 2003-2005 after qualifying the CSIR UGC NET examination (2004), has joined Maulana Azad Medical College (MAMC) in an ICMR project as an Senior Research Fellow and has been awarded with ICMR-SRF, Individual fellowship (2009-2010)  under the supervision of Dr. Premashis Kar, Director Professor Department of Medicine Maulana Azad Medical College, New Delhi. During the period of research at MAMC has also worked as Clinical research coordinator for well known drugs company like Bristol-Myers Squibb, Novartis and Lambda Therapeutics (2007-2010). Under the joint supervision of Prof. P Kar and Dr. M Deka has been awarded Ph.D. in the Year 2011, on host Genetic Factors TLR3 and MAVS in Hepatitis C Virus Infection from Gauhati University. In recognition of significant contribution for the advancement of Medical Sciences, has been elected as Member of the National Academy of Medical Sciencs (India) in the year 2017.

As group leader in the Laboratory of Molecular virology and Oncology (LMVO) in Department of Bioengineering and Technology, Gauhati University has completed -6  Research Project as PI, (DBT-4; ICMR-1; DHR-1)  in which the total grant received = 363.46 Lakhs, At present there is Two (2) ongoing project ,  (DHR-1, ICMR-1) Total grant sanctioned  = 147.94 Lakhs

The project has collaboration with Assam University Diphu campus, Gauhati Medical College and Hospital, Guwahati; Maulana Azad Medical College, New Delhi; Jamia Millia Islamia,New Delhi; G. B Pant Hospital, New Delhi; Assam Medical College, Dibrugarh, which can be envisaged from the publication. As on 20th June 2024 has 115 publications to his credit in both National and International peer reviewed journals and books. Has supervised 13 (Thirteen)  Ph.D.s till date in the field of Liver Diseases and GastroIntestinal cancer.

At present a Department of Health Research under Ministry of Health and Family welfare sponsored training programme on Molecular Biology/Molecular diagnostics (2024-2029) is held on regular interval to conducts basic and advance level molecular biology techniques among the students and research scholars of this region.

LMVO also served as Regional Research Centre along with ICMR-RMRC, in an ICMR-task force project for Molecular detection of Hepatitis A, Hepatitis B. Hepatitis C, Hepatitis D and Hepatitis E from all the major hospitals of Northeast India.

Has been the recepients of several awards and recognition during his career :

1. State Merit Scholarship during higher secondary School

2. NEC scholarship during B.Sc and M.Sc

3. Awarded  the 1st Prize for the Best Paper in the Oral Plenary Session at Annual Conference of the Indian Association for The Study of Liver

4. Indian Society of Gastroenterology WIN-Medicare Award-2008 Best Poster presentation in the 49th Annual Conference of the Indian Society of Gastroenterology.

5. Travel award by World Congress of Gastroenterology (WCG) in the Basic Scientist category (Awarded to the top100 paper worldwide) to attend the WCOG conference at London from 21st  to 25th Nov 2009.

6. Young Investigator Bursary award by EASL to attend the  EASL International Liver congress at  Vienna, Austria, from  14th  to 18th  April 2010.

7. Recipient of Young Investigator Bursary award by European Association for Study of Liver (EASL) to attend the EASL Monothematic Conference on Alcoholic Liver Disease held at Athens, Greece ,from 10th –12th December 2010.

8. Young Investigator Bursary award by EASL to attend  the  EASL Monothematic Conference: Translational Research in Chronic Viral Hepatitis - Bridging Basic Science and Clinical Research, 29th to 30th November 2013

9. Received ICMR International Fellowships for Young Biomedical Scientists 2013-14

Over the past decade he visited Singapore, UK, Austria, France, Greece, Netherland and Belgium for research and academic assignments. 

Research area at Laboratory of Molecular Virology and Oncology:

• Molecular Epidemiology of Viral Hepatitis and the Role of Host Genetic Factors.
• Role of Cell Cycle , DNA repair Gene in the development of Gastrointestinal (Oral, esophageal, Gastric ) Cancer.
• Evaluation and estimation of Toxic compund from the environments (Air/Food/water) and it role in high incidence of Cancer in Northeast India.
• Human Genetics

Completed Research Projects:

1. Department of Biotechnology, Govt. of India Sponsored twinning projects entitled " Prevalence of G6PD variants among the different tribal communities in Karbi anglong and Kokrajhar districts of Assam, Northeast India". 2010-14 (Total grant received Rs. 19,80,000/-)
2. Department of Biotechnology, Govt. of India Sponsored twinning projects entitled " Study the associative role of alteration(s) in cell cycle controller EZH2,Tumor supressor RUNX3, DNA repair gene MGMT and local food habits with the predisposition and severity of esophageal cancer". 2012-15 (Total grant received Rs. 68,08,000/-)
3. Department of Biotechnology, Govt. of India Sponsored twinning projects entitled "Polymorphism of IL28B gene and it association with response to treatment with Peg-Interferon and Ribavirin combination in Chronic Hepatitis C Virus Infection from Northeastern India". 2012-15 (Total grant received Rs. 71,58,000/-)
4. Indian Council of Medical Research, sponsored task force project entitled "A Systematic assessment of acute viral hepatitis and chronic liver disease in Northeast India with special reference to strengthening of laboratories in the region". 2018-2021 (Total grant received Rs. 77,25,680/-)
5. Department of Health Research Ministry of Health and Family welfare Govt. of India sponsored project entitled " Support to conduct training programme in the area of molecular-biology/ molecular diagnostic". 2018-2023 (Total grant received Rs. 68,74,500/-)
6. Department of Biotechnology, Govt. of India Sponsored project  entitled "To study the prevalence of resistance associated substitutions RASs in HCV patients and its correlation with aniviral treatment response". 2020-2024 (Total grant received Rs. 57,00,240/-)

Ongoing Research project:

1. Indian Council of Medical Research, sponsored project entitled“ Screening and Functional analysis of ALDH1L2 (rs199841702) and PNPLA3 (rs738409) germline variants in different cohorts of chronic liver
   diseases cases”. 2024-2027 (Total grant Sanctioned Rs 47,94,757)
2. Department of Health Research Ministry of Health and Family welfare Govt. of India sponsored project entitled " Support to conduct training programme in the area of “MOLECULAR BIOLOGY APPLICATIONS: RESEARCH AND DIAGNOSTIC TECHNIQUES”. 2024-2029 (Total grant Sanctioned Rs. 99,99,280/-)

Collaborator:

1. Department of Biosciences, Jamia Millia Islamia, New Delhi.
2. Department of Gastrointestinal Surgery, G.B.Pant Hospital, New Delhi.
3. Department of Virology and Department of Molecular and cellular Medicine, Institute of Liver and Biliary Science, New Delhi.
4. School of Life Science, Jawaharlal Nehru University, New Delhi.
5. Department of Medicine and Department of Microbiology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong.
6. Department of Biochemistry and Department of Medicine, Jawaharlal Nehru Institute of Medical Sciences, Imphal.
7. Department of Gastroenterology, Department of Microbiology, Department of Medicine, Guwahati Medical College and Hospital, Guwahati.
8. Department of Medicine and Department of Pathology, Assam Medical College, Dibrugarh.
9. Dr. B. Borooah Cancer Institute, Guwahati.
10. North East Cancer Hospital, Jorabat.
11. Regional Medical Research Centre (RMRC) ICMR, Dibrugarh.

•  B.Tech 1st and 2nd Semester- Biological Science (Common paper for all branch at GUIST)
• B.Tech 4th Semester- Molecular Biology 
• B.Tech 5th Semester- Genetic Engineering
• M.Tech 1st Semester- Molecular Virology (Elective paper)
• M.Tech 2nd Semester- Molecular Oncology (Elective paper)

• Entitled to National Merit Scholarship from Class-XI Onward
• Qualified Joint CSIR-UGC National Eligibility Test (NET) for lectureship held on 27.06.2004
• Awarded the 1^st Prize for the Best Paper in the Oral Plenary Session at Annual Conference of the Indian National Association for The Study of Liver-2007 on the paper entitled “Diagnostic Utility of Hepatitis C Virus core antigen assay in hemodialysis patients.
• ISG WIN-Medicare Award-2008 for the Best Poster presentation in the 49^th Annual Conference of the Indian Society of Gastroenterology (ISG).
• Travel award  by World Congress  of Gastroenterology (WCG)  in the  Basic  Scientist  category  (Awarded to  the top 100  paper  world wide) to attend the WCOG conference  at  London from  21^st  to  25^th  Nov 2009.
• Entitled to ICMR individual fellowship on the topic “Polymorphic Analysis of MHC-linked HSP70 Genes in Hepatocellular Carcinoma” from 1^st January 2009  to 24^th February 2010.
• EASL monothematic conference on signaling in liver organized in Amsterdam, The Netherlands from 18^th-20^th February 2010.
• European association of studies on liver ‘Young Investigator bursary award’ for presenting my research work in the EASL annual conferences held at Vienna, Austria from 14^th – 18^th April 2010.
• European association of studies on liver ‘Young Investigator bursary award’ for presenting my research work in the EASL monothematic conference on Alcoholic liver disease organized in Athens, Greece in from 10^th to 12^th December 2010.
• European association of studies on liver ‘Young Investigator bursary award’ for presenting my research work in the EASL Monothematic Conference : Translational Research in Chronic Viral Hepatitis- Bridging Basic Science and Clinical Research Nov 29-30, 2013 at Lyon France
• Received ICMR International Fellowships for Young Biomedical Scientists 2013-14 to work for 6 months with Gustavo J. Gutierrez Professor and Principal Investigator, Laboratory of Cell Cycle Control, Unit of Cellular Genetics, Department of Biology, Vrije Universiteit Brussel (VUB) Belgium.
• Elected as Member of National Academy of Medical Sciences (India) in recognition of significant contribution for the advancement of Medical Sciences-2017
• Awarded Dr. Dharamvir Datta Memorial Oration Award for research work in Liver Diseases in India for the year 2018 by Indian Council of Medical Research.

Laboratory of Molecular Virology & Oncology

Google Scholar Citations- 1095, h-index: 19

Scopus Citations-607, h-index: 14

https://scholar.google.com/citations?hl=en&user=KI6KGHYAAAAJ

https://www.scopus.com/authid/detail.uri?authorId=23668216800 

Total Research articles published till date: 112 

Research Articles published in Scopus indexed journals: 58 ( International - 54, National- 4)

Book Chapters Published - 3

Fellowship & Membership of Professional Societies:

• Life Member National Academy of Medical Science (India)
• Fellow member International Congress of Environmental Research
• Life member of the Indian Association for Cancer Research, India.
• Member of European Association for Study of Liver.
• Life Member of Indian National Association for Study of liver.
• Life member Indian Science Congress.
• Life Member Association of Microbiologist of India.

Reviewer & Editorial Board Member:

1. Expression of Toll like receptor-3 (TLR3) and Mitochondrial antiviral signaling protein (MAVS) in naïve and anti-viral therapy receiving patients with chronic hepatitis C virus infection Asia Pacific Association for Study of Liver – Beijing China March-2010 APASL- International

2. Role of Hepatitis C Virus (HCV) Infection with Mitochondrial antiviral signaling protein variations with HCV genotype and disease severity European Association for Study of liver held at Vienna, Austria 14th – 18th April 2010. EASL- International

3. High prevalence of cirrhosis in patients with alcoholic liver disease from northeast India European Association for Study of Liver (EASL) Monothematic conference on Alcoholic Liver Disease held at Athens, Greece 10th – 12th December 2010 EASL -International

4. Mitochondrial antiviral signaling (MAVS) gene polymorphism and it association with disease severity in Hepatitis C virus infection: A case control study Annual Conference - Indian Society of Gastroenterology, Young Investigator session held from 15th – 18th November 2010 at Hyderabad. Indian Society of Gastroenterology ISG - National

5. Toll-Like Receptor -3 (TLR3)And Mitochondrial Antiviral Signallintg Protein (MAVS) Expression in naïve And Anti- Viral Therapy Receiving Patients With Hepatitis C Virus Infection : A Pilot Study International Conference on Environment Genes Health Diseses. 9th – 11th December,2011 Human Molecular Genetic Laboratory, School of Life Sciences, Bharathiar University, Coimbatore - International

6. Differential Expression of Toll-Like Receptor 3 In Naïve And C Virus Infection International Conference on Medical Genetics and Genomics, 12th to 14th December 2011. Department of Biomedical Science, Bharathidasan University, Tamil Nadu-  International

7. Risk of hepatocellular carcinoma and its association with heat shock protein polymorphism in chronic liver disease patients from Indian population International Conference on Omics Meets Disease and IIIrd Annual Meeting. Of Proteomics Society (India) 15th to 18th December 2011 Saha Institute of Nuclear Physics (SINP)- International

8.  Nitric Oxide Synthase and hepatitis E infection Hepatol Int 2011 INASL- National

9. Characteristics of HCV related hepatocellular carcinoma in india-A case control study Hepatol Int 2011 INASL- National

10. Genetic Variants of heat shock protein A1L2437 and AlB1267 as possible risk factors for hepatocellular carcinoma in India 2nd Global Cancer Genomics Consortium-Tata Memorial Centre Symposium “Genomics Medicine in Cancer Research” 19th to 20th November 2012 Advanced Centre for Treatment Research and Education in Cancer, Navi Mumbai -International

11. Distribution of IL-28B Gene Polymorphism in Hepatitis C related Chronic liver disease from Northern and North-eastern India- A Pilot Study. Lyon, France, 29th – 30th November 2013 EASL- International

12. Risk factor associated with hepatitis A virus (HAV) and alcohol related liver disease severity-A molecular diagnosis based study from north eastern india Journal of hepatology 2012 EASL- International

13. Host immune statusand viral genotype in hepatitis C virus related liver disease severity in northeast india Journal of hepatology 2012 EASL-  International
14. Genetic variants of heat shock proteingene AIL2437 and A1B1267 and the possible risk factors for hepatocellular carcinoma in india Indian J Gastroenterol 2012 ISGCON 2012- National

15. Expression profile of toll like receptor 7 and TH1/TH2 dependent cytokines in acute viralhepatitis cases from assam:mA pilot study Indian journal gastroenterol-2013 ISGCON 2013 - National

16. Prevalance of hepatitis B virs genotype D in a tertiary care hospital in Guwahati, Assam Indian journal gastroenterol-2013 ISGCON 2013 National

17. Expression of TH1/TH2 cytokines in hepatitis B and C related chronic liver disease from assam Indian journal gastroenterol-2013 ISGCON 2013 -National

18. Study the role of differential expression profile of TLR2 and TLR9 in the deciding the susceptibility to malaria International Conference on Disease Biology and Therapeutics-2014 Institute of advance study of science and technology - International

19.  A comparative m RNA basedexpression study of toll like receptor 2 in hepatitis B virus mediated hepatocellular carcinoma and chronic hepatitis in north east india International Conference on Disease Biology and Therapeutics-2014 Institute of advance study of science and technology - International
20. Study of differential expression of adipokine and angiogenic markers and their association with alcoholic liver disease susceptibility International Conference on Disease Biology and Therapeutics-2014 Institute of advance study of science and technology-  International

21. Genetic polymorphism in DNA repair gene X ray repair cross complementation group 1 (XRCC1 Arg399Gin and Arg280His) gene and its correlation to develop Oesophageal Carcinoma in the north eastern population of india International Conference on Disease Biology and Therapeutics-2014 Institute of advance study of science and technology -International

22.  Expression analysis of TLR3, TLR7 and TLR9 in Nasopharyngeal carcinoma in north east india International Conference on Disease Biology and Therapeutics-2014 Institute of advance study of science and technology- International

23. Expression profile of toll like receptor 9 (TLR9) in acute hepatitis A related cases from kamrup district of assam International Conference on Disease Biology and Therapeutics-2014 Institute of advance study of science and technology -International

24. Analysis of Tripartite Motif Protein 25 (Trim25) polymorphism in naïve and treated chronic hepatitis C virus infected patients from north east india International Conference on Disease Biology and Therapeutics-2014 Institute of advance study of science and technology- International

25. Hepatitis B: Apublic health problemand its serological markers to diagnose nd to identify the stage of infection International Conference on Disease Biology and Therapeutics-2014 Institute of advance study of science and technology- International

26. Genetic polymorphism in DNA repair gene Xeroderma Pigmentosum Complementation Group D (XPD Lys751Gln, rs13181) gene and its correlation to develop Oesophageal Carcinoma in the North Eastern population of India. National Conference on Recent Advances in Cancer Biology and Therapeutics – 2014, 5th December 2014 Indian Institute of Technology, Department of Biotechnology, Guwahati -National

27. IL-28B Gene Polymorphism in Chronic Hepatitis C related liver disease patients in North-eastern India. 24th Annual State Conference of API, Assam Chapter and 4th Annual Conference of eastern Zone API- 2014, 12th to 14th December 2014 Association of Physician of India- National

28. High prevalence of mutant Tripartite Motif Protein 25 (Trim25) rs205498 polymorphism in Chronic Hepatitis C virus infected patients from North East India 2nd International Conference on Biotechnology & Bioinformatics (ICBB-2015) 6th to 8th February 2015 ICSCCB- International

29. Trim25 genotype SNP rs205498 is a better marker for prediction of treatment response than IL28B genotype SNP rs12979680 in patients with chronic hepatitis C Genotype 3 virus from Northeast India-A Pilot study Asian Pacific association for Study of the Liver (APASL) Single Theme Conference on HCV infection and Disease, December 18-20, 2015 APASL-  International

30. Polymorphism and mRNA level expression analysis of toll like receptor 3 gene in hepatocellular carcinoma Global Cancer Summit 2015, 18th to 20th November 2015 Global Cancer Summit -  International

31. Epstein barr virus (EBV) detection mRNA based expression analysis and single nucleotide polymorphism (SNP) study of toll like receptors (TLR3) in Nasopharyngeal carcinoma (NPC) patient group from north east india Global Cancer Summit 2015, 18th to 20th November 2015 Global Cancer Summit-  International

32. Relationship between promoter methylation & mRNA level expression of RUNX3 and MGMT gene in oesophageal cancer patients from north east india Global Cancer Summit 2015, 18th to 20th November 2015 Global Cancer Summit-  International

33. AICTE funded workshop under NEQIP programme on Lab view AICTE funded workshop under NEQIP programme on Lab view 27th to 28th March 2015 Physical Science Division, Department of Applied Sciences- Regional

34. AICTE funded workshop under NEQIP programme on Application of Bioinformatics in Medical Biotechnology AICTE funded workshop under NEQIP programme on Application of Bioinformatics in Medical Biotechnology, 24th april to 26th April 2015 Biological Science Division Department of Applied Sciences -Regional

35. Severity of Oesophageal carcinoma and its correlation with expression levels of O6-methylguanine-DNAmethyltransferase (MGMT) and Runt-related transcription factor 3 (RUNX3) genes in North Eastern region of India. 34th Annual Convention of Indian Association for Cancer Research on Cancer research: from Bench to the Bedside 19th to 21st February 2015 Indian Association for Cancer research- National

36. Personalized therapy of patients with chronic hepatitis C genotype 3 Virus from Northeast India based on TRIM 25 rs205498C/T besides IL28B rs12979680C/T screening predict better treatment response- A pilot study 57th Annual Conference of Association of Microbiologists of India & International Symposium on Microbes and Biosphere: What’s New What’s Next November 24th to 27th 2016 Department of Botany, Gauhati University & Institute of Advanced Study in Science and Technology (IASST)- International

37. Altered expression of MGMT and RUNX3 due to non CpG promoter methylation and their correlation with different risk factors on Oesophageal Cancer patients from Kamrup districts of Assam – Oral Presentation 36th Annual Conference of Indian Association for Cancer Research on The 21st Century – War on Cancer, February 9th to 11th IACR 2017 Indian Association for Cancer research National

1. Organized a free health camp for the village people of Dimoria, Khetri, Assam; and also provided health education to villagers on consultancy basis along with team of associated doctors and research scholars.

Educational qualification:

• Post Doctorate Fellowship- Department of Biology, Vrije Universiteit, Brussels (VUB), Belgium (2014)
• Ph.D- Department of Biotechnology, Gauhati University (2011)
• Post Graduate Diploma in Bioinformatics, Jamia Hamdard (2009)
• M.Sc- Departement of Biotechnology, Gauhati University (2002)
• B.Sc- Department of Biotechnology, St. Anthonys College, Shillong (2000)

Professional Experience held:

Associate Professor, Department of Bioengineering & Technology, Gauhati University, (GU), 25-02-2022 to Till date

Assistant Professor (Senior Scale), Department of Bioengineering & Technology , Gauhati University (GU), 23-11-2015  to 24-02-2022

Assistant Professor(Senior Scale), Department of Applied Sciences,  Gauhati University, From  01-10-2014 to 23-11-2015

Assistant Professor, Department of Biological Science,GUIST, Gauhati University, Guwahati, From 16-06-2011 To 30-09-2014

Assistant Professor, Department of Biotechnology, Gauhati University- Kokrajhar campus , Guwahati, Assam,From 25-02-2010 To 15-06-2011

Senior Research Fellow- ICMR, Department of Medicine, Maulana Azad Medical College, New Delhi, Individual fellowship from 01-01-2009 to24-02-2010

Clinical Research coordinator, Department of Medicine, Maulana Azad Medical College, New Delhi, From 28-08-2008 To 24-02-2010

Senior Research Fellow- ICMR, Department of Medicine, Maulana Azad Medical College, New Delhi, From 19-05-2005 To 30-09-2008

Faculty, Department of Biotechnology, Cyber Research & Training Institute (Under University of Burdwan),From 10-10-2003 To 18-05-2005

Research fellow, Division of Animal Health, ICAR Research Complex for NEH Region, Umiam, Shillong, From 03-01-2003 To 09-10-2003