MSc (Gauhati) PhD (Gauhati)
Microbial Biotechnology, Nanobiotechnology
Department of Bioengineering and Technology
Gauhati University, Guwahati, 781014
Email: dbaishya[at]gauhati[dot]ac[dot]in
B.TECH (Biotechnology)
1. Paper: Microbiology
2. Paper: Immunology
3. Paper: Process Engineering
4. Paper: Nano Biotechnology
5. Paper: Bioethics
6. Paper: Instrumentations
M. TECH (Bioprocess Technology)
Semester-I
1. Paper: Diversity and Molecular Biology of Microbes
2. Paper: Bioreaction Engineering
Semester-II
1. Paper: Instrumentations and Analytical methods in Bioengineering
2. Paper: Unit Operations in Bioprocessing
Ph.D. Coursework
1. Paper: Research Methodology
2. Paper: Microbiology and Immunotechnology (Optional Paper)
3. Paper: Research and Publication ethics
AREA OF RESERACH INTEREST
Microbial biotechnology, Nanomaterials, Natural products and drug discovery
Projetcts
Completed Project as PI : 1
Completed Project as Co-Pi: 3
Ongoing Project as PI: 1
Ongoing Project as Co-PI: 1
RESEARCH GROUP
Ph. D
Completed: 6 nos.
1. Sangeeta Baruah (Degree awarded, 2015)
Topic: Assessment of Genetic Diversity and Inheritance Study for Yellow Mosaic Virus Resistance in Soybean
2. Pori Deka (Degree awarded, 2016)
Topic: In vitro Propagation and Co-cultivation of Artemisia annua L. with Piriformospora indica for Enhancing the Production of Artemisinin and Expression of Related Genes
3. Sorra Sandhya (Degree awarded, 2017)
Topic: Identification of Potent Herbal Chemopreventive Agent
4. Joyeeta Talukdar (Degree awarded, 2017)
Topic: Study on Interaction between Cancer Stem Cells and Mesenchymal Stem Cells
5. Pranjal Sarmah (Degree awarded, 2019)
Topic: Identification of Potent Hepatoprotective Agent from Medicinal Plants of North East India
6. Seema Bhuyan (Degree awarded, 2023)
Topic: Targeting Cancer Stem Cells by BCG and Mycobacterium tuberculosis induced apoptosis
Thesis Submitted: 3 Nos.
Currently working:
Ph.d. Candidates: 4 Nos.
Post Doctoral Candidate: 1 No.
M. Tech Project students guided: 20 nos.
Current student: Nil
M. Sc. (Cancer Biology) Project Guided: 3
B. Tech Project students guided: 29 nos.
Current Student: 5 Nos.
1. Anusuya Ghatak
2. Himangshu Kakati
3. Darshita Choudhury
4. Bhumika Kashyap
5. Ananya Das
Research Publications: 50
Scopus h-index: 15; Google Scholar h-index: 17 (As on 19/4/2024)
Selected Research Publications:
24. Sorra Sandhya, Joyeeta Talukdar, Gayatri Gogoi, Kumar Saurav Dey, Bikul Das, Debabrat Baishya* (2024). "Impact of cocconut karnel extract on carcinogen-induced skin cancer model: oxidative stress, c-Myc proto-oncogene and tumor formation". Heliyon. 10: e29385. doi: https://doi.org/10.1016/j.heliyon.2024.e29385. (IF: 4.0).
23. Kaushik Kumar Bharadwaj,Iqrar Ahmad, Bijuli Rabha, Tanmay Sarkar, Harun Patel, Arabinda Ghosh, Debabrat Baishya (2024). “Screening of compounds for identification of prospective Histone Deacetylase 2 (HDAC 2) inhibitor: An in silico Molecular docking, Molecular Dynamics Simulation, and MM-GBSA approach”. Letters in Applied NanoBioScince. (Accepted)
22. Kaushik Kumar Bharadwaj, Bijuli Rabha, Iqrar Ahmad, Sam P. Mathew, Chandra Kanta Bhattacharjee, Bithiah Grace Jaganathan, Snikdha Poddar, Harun Patel, Vetriselvan Subramaniyan, Suresh V. Chinni, Gobinath Ramachawolran, Rasha Saleem, Eman Hussain Khalifa Ali, Mohamed M. Abdel-Daim, Debabrat Baishya*, Arabinda Ghosh (2023). “Rhamnetin, a nutraceutical flavonoid arrests cell cycle progression of human ovarian cancer (SKOV3) cells by inhibiting the Histone deacetylase 2 protein”. Journal of Biomolecular Structure and Dynamics. 28:1-16. DOI: https://doi.org/ 10.1080/07391102.2023.2275187 (IF: 4.4)
21. Kaushik Kumar Bharadwaj, Iqrar Ahmed, Siddhartha Pati, Arabinda Ghosh, Bijuli Rabha, Tanmay Sarkar, Dorothy Bhattacharjya, Harun Patel, Debabrat Baishya* (2023). "Screening of phytocompounds for identification of prospective Histone Deacetylase I (HDAC-I) inhibitor: An in silico Molecular Docking, Molecular Dynamics simulation, and MM-GBSA appraoch". Applied Biochemistry and Biotechnology (IF: 3.00). DOI: https://doi.org/10.1007/s12010-023-04731-3.
20. A Ghsoh, D Chakraborty, N Mukerjee, D Baishya, S Chigurupati, S G Felemban, S A Almahmoud, N Sharma, L Aleya, T Behl (2023)."Target based virtual screening and molecular interaction studies for lead identification of natural compounds against glioblastoma multiforme". Environmental Science and Pollution Research. 30: 6170-6191. Doi: https://doi.org/10.1007/s11356-022-22401-5. (IF: 5.19).
19. Seema Bhuyan, Bidisha Pal, Lekhika Pathak, Partha Jyoti Saikia, Shrisajit Mitra, Sukanya Gayan, Reza Bayat Mokhtari, Hong Li, Chilakamarti V. Raman, Debabrat Baishya, Bikul Das (2022). "Targeting hypoxia-induced tumor stemness by activating pathogen-induced stem cell niche defence". Frontiers in Immunology, 13: 933329. Doi:10.3389/fimmu.2022.933329. (IF: 8.786).
18. Kaushik Kumar Bharadwaj, Iqrar Ahmad, Siddhartha Pati, Arabinda Ghosh, Tanmay Sarkar, Bijuli Rabha, Harun Patel, Debabrat Baishya*, Hisham Atan Edinur, Zulhisyam Abdul Kari, Muhammad Rajaei Ahmad Mohd Zain, Wan Rosli Wan Ishak (2022). "Screening of potent bioactive compounds from edible seaweed waste to combat cancer: A Molecular dynamic and DFT approach". Frontiers in Nutrition, 9:889276. Doi: 10.3389/fnut.2022.889276 (IF: 6.590)
17. Arabinda Ghosh, Pranjal Sarmah, Harun Patel, Nobendu Mukharjee, Rajbardhan Mishra, Saad Alkahtani, Rajender S. Varma, Debabrat Baishya* (2022). "Nonlinear Molecular Dynamics of Quercetin in Gynocardia odorata and Diospyros malabarica fruits: its mechanistic role in hepatoprotection", Plos One, 17(3):e0263917. Doi: https://doi.org/10.1371/journal.pone.0263917 (IF: 3.752)
16. Nobendu Mukharjee, Anubhav Das, Swastika Maitra, Arabinda Ghosh, Prattusha Khan, Athanasios Alexious, Abhijit Dey, Debabrat Baishya, Faizan Ahmad, Punya Sachdeva, Muhanna K. Al-Muhanna (2022). "Dynamics of natural product Lupenone as a potential fusion inhibitor against the spike complex of novel Semliki Forest Virus", Plos One, 17(2): e0263853. https://doi.org/10.1371/journal.pone.0263853 (IF 3.752)
15. Arabinda Ghosh, Nobendu Mukharjee, Bhavdeep Sharma, Anushree Pant, Jugal K Mohanta, Rahul D Jawarkar, Rabindrakumar L Bakal, Ermias Mergia Terefe, Gaber El-Saber Bathia, Mohammed Alqarni, Abhijit Dey, Debabrat Baishya* (2022). "Target specific inhibition of protein Tyrosine Kinase in conjuction with cancer and SARS-COV-2 by olive nutraceutical". Frontiers in Pharmacology, 12: 812565. doi: 10.3389/fphar.2021.812565 (IF 5.998).
14. Bijuli Rabha, Kaushik Kumar Bharadwaj, Siddhartha Pati, Bhabesh Kumar Choudhury, Tanmay Sarkar, Zulhisyam Abdul Kari, Hisham Atan Edinur, Debabrat Baishya*, Leonard Lonut Atanase (2021). "Development of polymer-based nanoformulations for glioblastoma brain cancer therapy and diagnosis: an update" Polymers. 13: 4114 (IF: 4.967).
13. Kaushik Kumar Bharadwaj, Bijuli Rabha, Bhabesh Kumar Choudhury, Rosnina Rosalin, Tanmay Sarkar, Debabrat Baishya, Naorem Bidyaleima Chanu, Yengkhom Disco Singh, Manasa Kumar Panda, Siddhartha Pati (2021). “Current strategies in inhibiting biofilm formation for combating urinary tract infections: Special focus on peptides, nano-particles and phytochemicals”, Biocatalysis and Agricultural Biotechnology, 38: 102209. (IF 4.0)
12. Kaushik Kumar Bharadwaj, Bijuli Rabha, Siddhartha Pati, Tanmay Sarkar, Bhabesh Kumar Choudhury, Arpita Barman, Dorothy Bhattacharjya, Ankit Srivastava, Debabrat Baishya*, Hisham Attan Edinur, Zulhisyam Abdul Kari, Noor Hashlina Noor (2021). "Green synthesis of gold nanoparticles using plant extracts as beneficial prospects for cancer theranostics". Molecules, 26: 6389 (IF: 4.927).
11. Bijuli Rabha, Kushik Kumar Bharadwaj, Nizum Boro, Arabinnda Ghosh, Sonit Kumar Gogoi, Rajender S. Varma, Debabrat Baishya* (2021). "Cheilocostus speciosus extract-assisted and naringenin-encapsulated poly-Epsilon-caprolactone nanoparticles: evaluation of antiproliferative activities". Green Chemistry, 23: 7701-7711. DOI: 10.1039/d1gc02260a. (IF: 11.034)
10. Kaushik Kumar Bharadwaj, Bijuli Rabha, Siddhartha Pati, Bhabesh Kumar Choudhury, Tanmay Sarkar, Sonit Kumar Gogoi, Nayanjyoti Kakati, Debabrat Baishya*, Zulhishyam Abdul Kari, Hissam Attan Edinur (2021). "Green synthesis of silver nanoparticles using Diospyros malabarica fruit extract and assessment of their antimicrobial, anticancer and catalytic reduction of 4-nitrophenol (4-NP)". Nanomaterials, 11: 1999. https://doi.org/10.3390/nano11081999 (IF: 5.719)
9. Kaushik Kumar Bharadwaj, Tanmay Sarkar, Arabinda Ghosh, Debabrat Baishya, Bijuli Rabha, Manasa Kumar Panda, Bryan R. Nelson, Hassan I. Seikh, Hissam A. Edinur, Bisnu Parasd Dash, Akbor John, Siddhartha Pati (2021). "Macrolactin A as a novel inhibitory agent for SARS-CoV-2 Mpro: Bioinformatics approach", Applied Biochemistry and Biotechnology. doi: 10.1007/s12010-021-03608-7 (IF: 3.094).
8. Arabinda Ghosh, Anshuman Chandra, Avinash Dhar, Pratyoosh Shukla, Debabrat Baishya* (2021). “Multi-efficient thermostable endoxylanase from Bacillus velezensis AG20 and its production of xylooligosaccharides as efficient prebiotics with anticancer activity”, Process Biochemistry. 109: 59-71. (IF 4.885)
7. Lekhika Pathak, Sukanta Gayan, Bidisha Pal, Joyeeta Talukdar, Seema Bhuyan, Sorra Sandhya, Herman, Yeger, Debabrat Baishya, Bikul Das (2021). “Coronavirus Activates an Altruistic Stem Cells Mediated Defense Mechanism that Reactivates Dormant Tuberculosis: Implications in Coronavirus Disease 2019 Pandemic”. The American Journal of Pathology. 191(7):1255-1268 (IF 5.77).
6. Bijuli Rabha, Kaushik Kumar Bharadwaj, Debabrat Baishya*, Tanmay Sarkar, Hisam Atan Edinur, Siddhartha Pati (2021)."Synthesis and Characterization of Diosgenin Encapsulated Poly--Caprolactone-Pluronic Nanoparticles and Its Effect on Brain Cancer Cells”, Polymers. 13: 1332. (IF 4.967).
5. Santanu Dhar, Mamta Bhattacharjee, Debabrat Baishya*, Sumita Achargee (2021). “Characterization of seed proteome profile of wild and cultivated chickpeas of India”, Protein and Peptide Letters. 28:323-332. (IF 1.927)
4. Bikul Das, Bidisha Pal, Rashmi Bhuyan, Hong Li1, Anupam Sarma, Sukanya Gayan, Joyeeta Talukdar, Sorra Sandhya, Seema Bhuyan, Gayatri Gogoi, Arvin M. Gouw, Debabrat Baishya, Jason R. Gotlib, Amal Chandra Kataki and Dean W. Felsher (2019). “MYC regulates the HIF-2α stemness pathway via Nanog and Sox2 to maintain self-renewal in cancer stem cells versus non-stem cancer cells”, Cancer Research. Doi: 10.1158/0008-5472.CAN-18-2847 (IF 13.312)
3. Arabinda Ghosh, Saikat Sutradhar, Debabrat Baishya* (2019). “Delineating thermophilic xylanase from Bacillus licheniformis DM5 towards its potential application in xylooligosaccharides production”, World Journal of Microbiology and Biotechnology Vol. 35: 34-41 (IF 4.253).
2. Sumit Kumar, Arun K Dangi, Pratysh Shukla, Debabrat Baishya, Sunil K Khare (2019). "Thermozymes: adaptive strategies and tools for their biotechnological application", Bioresource Technology Vol 278: 372-382 (IF: 11.889).
1. Debabrat Baishya*, Pori Deka and Mohan Chandra Kalita (2015). “In vitro co-cultivation of Piriformospora indica filtrate for improve biomass productivity in Artemisia annua (L.)”, Symbiosis Vol. 66: 37-46. DOI 10.1007/s13199-015-0331-5 (IF: 3.109).
BOOK
1. Fish Fermentation: Traditional To Modern Approaches, Debabrat Baishya and Manab Deka (2009). New India Publishing Agency, New Delhi, India.
Book Chapter
1. Role of Machine Intelligence in Cancer Drug Discovery and Development, In: Advanced AI Techniques and Applications in Bioinformatics. Kaushik Kumar Bhaeadwaj, Bijuli Rabha, Gaber El-Saber Batiha, Debabrat Baishya and Arabinda Ghosh. Edited By Lovleen Gaur, Arun Solanki, Samuel Fosso Wamba, Noor Zaman Jhanjhi. 1st Edition; Published by CRC Press on 18-10-2021. DOI: http://doi.org/10.1201/9781003126164. eBook ISBN: 9781003126164.
2. Role of Gold Nanoparticles Against Multidrug Resistance (MDR) Bacteria: An Emerging Therapeutic Revolution. Kaushik Kumar Bharadwaj, Bijuli Rabha, Bhabesh Kumar Choudhury, Aditi Das, Lydia Islary, Dorothy Bhattacharjya, Monoswy Chakraborty, Debabrat Baishya, Arabinda Ghosh. Published by Springer on 1 -10-2022 (first online). DOI: 10.1007/978-3-030-84126-3_22.
3. Unravelling the Genomics and Proteiomics Aspects for Understanding the Stemness Phenotype in Stem Cells, In: Computational Biology for Stem Cell Research. Sorra Sandhya, Kaushik Kumar Bharadwaj, Joyeeta Talukdar and Debabrat Baishya. Edited by Dr. Pawan Kumar Raghav. Published by Elsevier, Academic Press, eBook ISBN: 9780443132216 Published on January 22, 2024.
Applied For
1. Designing and Synthesis of a Novel Anti-cancer Peptide for Polymer Nanoparticle based Targeted Drug Delivery to treat cancer (Application No. 202431020874 dtd. 19/3/2024).
1. Head i/c, Department of Bioengineering and Technology (20/10/2014 to 30/12/2015)
2. Head i/c, Department of Bioengineering and Technology (3/11/2016 to 10/1/2017)
3. Head i/c, Department of Bioengineering and Technology (20/3/2017 to 25/6/2017)
4. Head i/c, Department of Bioengineering and Technology (8/1/2020 to 19-1-2023)
5. Chairperson, DRC, Department of Bioengineering and Technology (2014-15; 2016-17; 2020-2023)
6. Chairperson, DAC, Department of Bioengineering and Technology (2014-15; 2016-17; 2020-2023)
7. Chairperson, CCS, Department of Bioengineering and Technology (2014-15; 2016-17; 2020-2023)
8. Memebr, Academic Council, GU (2020-2023)
9. Member, Institutional Biosafety Committee (2021 till date)
10. Co-ordinator, Equity Action Plan, GU, TEQUIP III programme funded by AICTE, India
Engagement in Other Universities/Institutions
1. External Member, DRC, Department of Molecular Biology and Biotechnology, Cotton University (27-10-2017 to 26-10-2019)
2. Outside Expert Member, IBSC, Cotton University (9-3-2020 t0 8-3-2023)
3. Outside Expert Member, IBSC, B. Borooah Cancer Institute, Guwahati, Assam (March 2021 to March 2024)
4. DBT Nominee, IBSC, Assam Agricultural University, Jorhat, Assam (30-8-2023 to 29-8-2026)
ASSOCIATION WITH ACADEMIC BODIES/SOCIETIES/JOURNALS
1. Life Member, Association of Carbohydrate Chemists and Technologists India (ACCTI) (From 2018)
2. Life Member, Association of Microbiologists of India ( From 2016)
3. Member, Society for Ethnopharmacology, Kolkata (2014 to 2018)
4.. Life Member, North East Biotechnological Association (NEBA), Guwahati, Assam (From 2005)
5. Life Member, Assam Science Society, Guwahati, Assam
6. Review Editor, Frontiers in Bioengineering and Biotechnology (Section: Bioprocess Engineering)
2022: R K Borkotoky best Research paper award by Cancer Research Foundation, India
Resourse Person, Experts, Invited Talk deliverd in last 5 Years (2019-2023)
1. Invited Speaker in Assam Botany Congress and “International conference on plant science” (Feb. 4-6/2019). Organized by Department of Botany, Gauhati University, Cotton University, Assam Down Town University and Assam Science Technology and Environment Council, Assam.
2. Invited Guest Speaker in “International Webinar on Nanotechnology in Agriculture and Biotechnology” on the topic “Nanobiotechnology: Scope and its role in Drug delivery” held from 19-21 October 2020 organized by Department of Agriculture Biotechnology and Molecular Biology; CBS & H and Department of Seed Science and Technology, Dholi and Dr. Rajendra Prasad Central Agricultural University, Pusa, Bihar.
3. Invited Speaker in “Assam Botany Congress and International Conference on Plant Science” on the topic “Biogenesis of biodegradable polymer nanoparticles for sustainable release of drug with reference to biomedical applications” held from 3-5 December 2021 organized by Botanical Society of Assam, Guwahati and Department of Botany, Cachar College.
4. Expert in Industry-Academia Panel Discussion in CARBO-XXXVI, International Carbohydrate Conference on “Emerging Trends in Glycochemistry, Glycobiology and Technology”, held from 5-7 December 2022 and organized by IIT Bombay in association with Association of Carbohydrate Chemists and Technologists, India.
5. Invited Speaker in National seminar on Nanobiotechnology in Biotherapeutics: Advancement in Drug Discovery, Development and Delivery systems” held from 16-18 November 2023 organized by Department of Pharmaceutical Sciences and Center for Biotechnology and Bioinformatics, Dibrugarh University, Dibrugarh, Assam.
6. Invited Speaker in CARBO XXXVII, International Conference on Basic, Analytical and Allied Sciences at the Interface of Carbohydrates and Biomass Valorization” held from 30th November to 2nd December 2023 organized by Delhi Technological University in association with Association of Carbohydrate Chemists and Technologists, India, New Delhi, India.
7. Resource Person in the Faculty Development Programme on “Electrophoretic Analysis of Protein and DNA” organized by Advanced Level Institutional Biotech-Hub, Handique Girls College, Guwahati, Assam, India dated 5/12/2023.
1. Organized International conference on “Green Energy and smart materials through Science, Technology and Management” as Co-Convenor of Organizing Committee (21-23 January, 2014)
2. Organized National Seminar on “Emerging Bio-inputs in Biotechnology for a green environment” as organizing Secretary (9-10 May, 2014) in the Department of Bioengineering and technology.
3. Organized workshop on “Nanotechnology and Bioinformatics: Application at Interface” (6-7 February, 2015) in the Department of Bioengineering and technology.
4. Organized a CME cum workshop on “Good laboratory practice and Drug Development” (4-5 October 2021) in the Department of Bioengineering and technology.
5. Organized an Advanced Entrepreneurship and Skill Development Program (E-SDP) on "Entrepreneurship promotion in the area of waste management" (19-23 February 2024) in collaboration with School of Energy Science and Engineering IIT Guwahati and funded by MSME.